What advantage do nonionized drugs have in intravenous administration?

Nonionized drugs have the significant advantage of being more easily absorbed in the body, which makes option B the correct choice. This is primarily due to the physicochemical properties of nonionized compounds. In pharmacology, the degree of ionization of a drug can influence its solubility and permeability across biological membranes.

Nonionized drugs are more lipophilic, meaning they can more easily cross cell membranes, including the blood-brain barrier and other tissue barriers. This enhances their absorption, particularly in intravenous administration, where drugs need to directly enter the bloodstream and be distributed throughout the body.

The other options do not accurately reflect the pharmacokinetic advantages of nonionized drugs during intravenous administration. Nonionized drugs typically do not cause increased side effects or require larger doses compared with ionized drugs. Additionally, nonionized drugs are generally more effective due to their ability to reach target tissues more easily and in appropriate concentrations. Therefore, the ease of absorption provided by being nonionized contributes significantly to their effectiveness when administered via intravenous routes.