What can be a result of prolonged use of NSAIDs?

Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to gastrointestinal bleeding due to the way these medications work in the body. NSAIDs inhibit the enzyme cyclooxygenase (COX), which is important for the production of prostaglandins. Prostaglandins play a crucial role in maintaining the protective lining of the stomach and intestines as well as regulating gastric acid secretion. When NSAIDs reduce the levels of these protective prostaglandins, the gastrointestinal mucosa becomes more vulnerable to injury, resulting in conditions such as ulcers and, ultimately, bleeding.

Moreover, the risk of gastrointestinal bleeding increases with factors such as the duration of NSAID use, dosing, and the presence of other risk factors like older age, concurrent use of other medications (for instance, anticoagulants), or a history of peptic ulcer disease. Managing these risks is crucial for patients who require long-term NSAID therapy, highlighting the importance of regularly monitoring and possibly using protective agents like proton pump inhibitors in such situations.