What does the term "drug tolerance" mean?

The term "drug tolerance" specifically refers to a phenomenon where a patient's response to a medication diminishes over time with continued use. This occurs when the body adapts to the presence of the drug, leading to a decreased efficacy of the medication at the same dosage. As a result, the individual may find that the initially effective dose no longer produces the desired therapeutic effect, prompting the need for a higher dose in order to achieve the same response. This concept is particularly relevant in the context of certain medications, such as opioids and benzodiazepines, where the risk of tolerance can significantly affect treatment plans and patient management. Understanding drug tolerance is crucial for prescribers to navigate medication adjustments and keep patient safety at the forefront of their practice.