What is the main reason for not crushing a sustained-release capsule?

The main reason for not crushing a sustained-release capsule is that doing so can cause toxicity. Sustained-release formulations are specifically designed to release the medication gradually over an extended period. When these capsules are crushed, the controlled release mechanism is disrupted, leading to the rapid release of the entire dose at once. This can result in peak plasma concentrations that exceed safe therapeutic levels, potentially leading to adverse effects or toxicity. The complexity of drug absorption and metabolism can be significantly altered, putting the patient at risk.

In contrast, options regarding reduced efficacy or enhanced absorption do not accurately depict the primary concern, which is safety. While the taste may be a minor issue in some cases, the risk of toxicity is far more critical when it comes to sustained-release medications. Prescribers must ensure that patients receive medications in their intended formulation to maintain therapeutic effectiveness and minimize the risk of harm.