What long-term risk is associated with the use of proton pump inhibitors (PPIs)?

The long-term use of proton pump inhibitors (PPIs) has indeed been associated with an increased risk of kidney disease. Studies have shown that prolonged PPI therapy can lead to acute interstitial nephritis and, over time, may contribute to chronic kidney disease. This association raises concern for healthcare providers when prescribing these medications, especially for long-term management of conditions like gastroesophageal reflux disease (GERD) and peptic ulcers.

In contrast, the other options do not reflect established associations with PPI use. High blood pressure is not typically linked to PPIs, and there is no evidence suggesting that these drugs enhance liver function or increase red blood cell count. On the contrary, chronic use of PPIs has been scrutinized due to potential complications, especially in populations using them for extended periods. This makes awareness of kidney health particularly pertinent for patients on long-term PPI regimens.