Which of the following is NOT a recommended action to minimize drug-drug interactions?

Prescribing a third drug to counteract the adverse reaction of the combination is not an effective approach to minimizing drug-drug interactions because it can lead to a more complex medication regimen and potentially introduce additional drug-drug interactions. Instead of resolving the issue, this method can complicate the patient's treatment and may result in further complications, increased side effects, and a higher risk of adverse reactions.

In clinical practice, strategies to minimize drug-drug interactions typically involve adjusting the existing medications rather than adding another one. Reducing the dosage of one or both drugs can alleviate the potential interaction effects. Additionally, spacing the administration times allows for adequate absorption and metabolism of each drug, thus reducing the likelihood of interaction at the pharmacokinetic or pharmacodynamic level. These methods directly address the interaction with a focus on optimizing the current medication regimen and maintaining therapeutic efficacy while minimizing risks.